COI Publications

Latest publications

Tetraspanin-based immunocapture for high-depth proteomic profiling of extracellular vesicles from cerebrospinal fluid for biomarker discovery

Dellar ER. et al, (2026), Clinical Proteomics, 23

Deformation-Recovery diffusion model (DRDM): Instance deformation for image manipulation and synthesis

Zheng J-Q. et al, (2026), Medical Image Analysis, 110, 103987 - 103987

Facilitators may represent a new class of regulatory elements.

Kassouf M. et al, (2026), Current opinion in genetics & development, 97

Ubiquitin E3 ligase KLHL6 brings exhausted T-cells back into action

Chen Z. et al, (2026), Immunity & Inflammation, 2

Vaccine effectiveness of a bivalent respiratory syncytial virus (RSV) pre-F vaccine against RSV-associated hospital admission among adults aged 75–79 years in England: a multicentre, test-negative, case–control study

Symes R. et al, (2026), The Lancet Infectious Diseases, 26, 229 - 238

COI Affiliated Publications (First author/ Corresponding author)

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Dejnirattisai W. et al, (2022), Cell, 185, 467 - 484.e15

Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study

Costa Clemens SA. et al, (2022), The Lancet, 399, 521 - 529

Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers

Wang W. et al, (2022), Journal of Biological Rhythms, 37, 124 - 129

n immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Peng Y. et al, (2022), Nature Immunology, 23, 50 - 61

bsolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

Lee JY. et al, (2022), eLife, 11

blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Ahern DJ. et al, (2021)

Reduced neutralisation of SARS-CoV-2 omicron B.1.1.529 variant by post-immunisation serum

Dejnirattisai W. et al, (2022), The Lancet, 399, 234 - 236

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

Liu C. et al, (2022), Cell Host & Microbe, 30, 53 - 68.e12

Publications

ZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T H 1 response with a diverse TCR repertoire

Swanson PA. et al, (2021), Science Translational Medicine, 13

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

de Silva TI. et al, (2021), iScience, 24, 103353 - 103353

Priority index: database of genetic targets in immune-mediated disease

Fang H. and Knight JC., (2022), Nucleic Acids Research, 50, D1358 - D1367

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

Zhuang X. et al, (2021)

Immunodominance complexity: lessons yet to be learned from dominant T cell responses to SARS-COV-2

Wellington D. et al, (2021), Current Opinion in Virology, 50, 183 - 191

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Feng S. et al, (2021), Nature Medicine, 27, 2032 - 2040

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)

Flaxman A. et al, (2021), The Lancet, 398, 981 - 990

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

Liu C. et al, (2021), Cell, 184, 4220 - 4236.e13

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

Wing PAC. et al, (2021), Cell Reports, 35, 109020 - 109020

ntibody evasion by the P.1 strain of SARS-CoV-2

Dejnirattisai W. et al, (2021), Cell, 184, 2939 - 2954.e9

aemagglutination test for rapid detection of antibodies to SARS-CoV-2

Townsend A. et al, (2021), Nature Communications, 12

Host genetics and infectious disease: new tools, insights and translational opportunities

Kwok AJ. et al, (2021), Nature Reviews Genetics, 22, 137 - 153

IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans

Wellington D. et al, (2021), European Journal of Immunology, 51, 742 - 745

The antigenic anatomy of SARS-CoV-2 receptor binding domain

Dejnirattisai W. et al, (2021), Cell, 184, 2183 - 2200.e22

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

Supasa P. et al, (2021), Cell, 184, 2201 - 2211.e7

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Zhou D. et al, (2021), Cell, 184, 2348 - 2361.e6

Publications

DUB esterase activity further decodes ubiquitin’s enigma

Kessler BM., (2021), Proceedings of the National Academy of Sciences, 118

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

Pinto-Fernandez A. et al, (2021), British Journal of Cancer, 124, 817 - 830

Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities

Liang Z. et al, (2021), Cell Communication and Signaling, 19

Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.

Sengupta S. et al, (2021), Journal of biological rhythms, 36, 23 - 34

Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter

Wing PAC. et al, (2021), Journal of Hepatology, 75, 64 - 73

COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Tan TK. et al, (2021), Nature Communications, 12

Malignancy and IFITM3: Friend or Foe?

Rajapaksa US. et al, (2020), Frontiers in Oncology, 10

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Peng Y. et al, (2020), Nature Immunology, 21, 1336 - 1345

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

Zhou D. et al, (2020), Nature Structural & Molecular Biology, 27, 950 - 958

Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

Zhao Y. et al, (2020), JCI Insight, 5

Human cancer germline antigen-specific cytotoxic T cell—what can we learn from patient

Abd Hamid M. et al, (2020), Cellular & Molecular Immunology, 17, 684 - 692

Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019

Zhang Y. et al, (2020), The Journal of Infectious Diseases, 222, 34 - 37

Novel Scoring System for Prediction of Disease Severity in COVID-19

Zhang C. et al, (2020), Frontiers in Cellular and Infection Microbiology, 10

Defective Interferon Gamma Production by Tumor-Specific CD8+ T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter

Abd Hamid M. et al, (2020), Frontiers in Immunology, 11

Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses

Abd Hamid M. et al, (2020), Cancer Immunology Research, 8, 203 - 216

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans

Rijal P. et al, (2020), Journal of Virology, 94

Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer

Li X. et al, (2019), Frontiers in Oncology, 9

Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses

Abd Hamid M. et al, (2019), Cancer Immunology Research, 7, 1293 - 1306

IFITM3: How genetics influence influenza infection demographically

Wellington D. et al, (2019), Biomedical Journal, 42, 19 - 26

COI Affiliated Publications (non-first author/ corresponding author)

Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial

Stuart ASV. et al, (2022), The Lancet, 399, 36 - 49

Why do breakthrough COVID-19 infections occur in the vaccinated?

Maclean P. et al, (2022), QJM: An International Journal of Medicine, 115, 67 - 68

Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence.

Riedl T. et al, (2021), Hepatology (Baltimore, Md.), 74, 1766 - 1781

Promises and challenges of adoptive T-cell therapies for solid tumours

Morotti M. et al, (2021), British Journal of Cancer, 124, 1759 - 1776

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

Ogbe A. et al, (2021), Nature Communications, 12

Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine.

Watanabe Y. et al, (2021), ACS central science, 7, 594 - 602

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

Ryzhakov G. et al, (2021), Nature Communications, 12

Immune Responses to a Single Dose of the AZD1222/Covishield Vaccine at 16 Weeks in Individuals in Sri Lanka

Jeewandara C. et al, (2021), The Journal of Immunology, 207, 2681 - 2687

Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Skelly DT. et al, (2021), Nature Communications, 12

Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.

Melidis L. et al, (2021), Angewandte Chemie (International ed. in English), 60, 18144 - 18151

Reactivation of a developmentally silenced embryonic globin gene

King AJ. et al, (2021), Nature Communications, 12

Publications

Pleural Fluid Has Pro-Growth Biological Properties Which Enable Cancer Cell Proliferation

Asciak R. et al, (2021), Frontiers in Oncology, 11

HLA-E–restricted, Gag-specific CD8 + T cells can suppress HIV-1 infection, offering vaccine opportunities

Yang H. et al, (2021), Science Immunology, 6

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Voysey M. et al, (2021), The Lancet, 397, 881 - 891

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Barrett JR. et al, (2021), Nature Medicine, 27, 279 - 288

Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison

Ainsworth M. et al, (2020), The Lancet Infectious Diseases, 20, 1390 - 1400

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Ramasamy MN. et al, (2020), The Lancet, 396, 1979 - 1993

Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments

Kanellakis NI. et al, (2020), Thorax, 75, 1004 - 1008

Ubiquitomics: An Overview and Future

Vere G. et al, (2020), Biomolecules, 10, 1453 - 1453

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Huo J. et al, (2020), Nature Structural & Molecular Biology, 27, 846 - 854

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

Huo J. et al, (2020), Cell Host & Microbe, 28, 445 - 454.e6

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial (vol 396, pg 467, 2020)

Folegatti PM. et al, (2020), LANCET, 396, 466 - 466

Clinical and epidemiological features of COVID-19 family clusters in Beijing, China

Song R. et al, (2020), Journal of Infection, 81, e26 - e30

Biological effect of tissue plasminogen activator (t-PA) and DNase intrapleural delivery in pleural infection patients

Kanellakis NI. et al, (2019), BMJ Open Respiratory Research, 6, e000440 - e000440

Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study

Lindsey BB. et al, (2019), The Lancet Respiratory Medicine, 7, 665 - 676

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

Saliba DG. et al, (2019), eLife, 8

Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse

Felce JH. et al, (2021), Frontiers in Cell and Developmental Biology, 8

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Voysey M. et al, (2021), The Lancet, 397, 99 - 111

COI Affiliated Publications—Preprints (first/corresponding author)

bsolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences

Lee JY. et al, (2021)

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Latest publications

COI Affiliated Publications (First author/ Corresponding author)

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COI Affiliated Publications (non-first author/ corresponding author)

Publications

COI Affiliated Publications—Preprints (first/corresponding author)