Contact information
Research groups
Yanchun Peng
Senior Research Associate
- DPhil Supervisor
- Human T cell bank team
Reseach Profile
My research focuses on how antigen-specific T cells contribute to the control of viral infections and cancer, using single-cell transcriptomics, multi-omic profiling, and functional immune assays to study immune regulation and cytotoxic T cell mechanisms.
I completed my DPhil in Clinical Medicine at Oxford in 2013, studying HLA-B51–associated HIV-1 viral control. Since then, my work has expanded to include HIV, Hepatitis C, SARS-CoV-2, Mpox, and influenza, as well as tumour-reactive T cells in cancers such as lung cancer and melanoma. Together with colleagues, I have established the Human T Cell Bank at the Institute, comprising antigen-specific T cell clones and lines targeting hundreds of viral and tumour antigens.
Alongside my research, I have served as Assistant Director of Graduate Studies at the Institute for the past four years. I also supervise DPhil students across a range of immunology projects. I am committed to mentoring early-career scientists and advancing translational immunology.
Recent publications
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Immunogenicity of MVA-BN vaccine deployed as mpox prophylaxis: a prospective, single-centre, cohort study and analysis of transcriptomic predictors of response
Journal article
Drennan PG. et al, (2025), The Lancet Microbe, 6, 101045 - 101045
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Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination
Journal article
Yin Z. et al, (2023), Cell Reports, 42, 112470 - 112470
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Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination.
Journal article
Yin Z. et al, (2023), Cell Rep, 42
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T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
Journal article
Céspedes PF. et al, (2022), Nature Communications, 13
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T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
Journal article
Céspedes PF. et al, (2022), Nature Communications, 13