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Screaton & Mongkolsapaya Group | Antibody Responses to emerging pathogens
Our main research is to understand immune-responses, particularly antibody responses, against emerging pathogens, such as dengue virus, zika virus, HIV, Ebola virus, SARS and MERS and, the most recent, SARS-CoV2.
Rijal Group | Antibodies and Vaccines targeting Influenza virus
Our research focuses on the influenza virus neuraminidase protein as a promising target for both disease prevention and therapeutic strategies, including vaccines, drugs, and antibodies.
Cespedes-Donoso Group | Post-Translational Control of Lymphocyte Communication
Our group focuses on understanding how protein post-translational modification (PTM) enzymes modulate cell-cell communication in health and disease. PTMs diversify the biochemical and biophysical properties of proteins modulating trafficking, membrane diffusion, supramolecular organisation, stability, recycling, binding to cognate ligands and sorting into extracellular particles. Our mission is to discover the overarching hierarchy of enzymes modulating the intercellular networks of human immunity.
Chen Group | Lipid-mediated T cell immunity
Translational Research on the Pathogenesis and Therapeutic Strategies for Bacterial Infection–Derived Autoimmune Sequelae
Wing Group | Molecular Virology
Viruses impact all levels of cellular biology and our lab studies these molecular interactions to understand the intricate interplay between a virus and its host cell. We characterise viral infections using cutting edge imaging and molecular tools in a variety of primary and cell-line based models. Our particular focus is understanding how viruses impact the homeostatic balance of cellular physiology and pathology.
Fernandes Group | Immune signalling in health & disease
• Dissecting and manipulating immune receptor signalling • Discovery-led approaches to guide the engineering of novel proteins that potentiate robust immune responses against tumours and infection • Developing methods to identify targets of immune recognition
Kanellakis Group | Translational Pleural Research
Laboratory of Translational Pleural Research
IPP Group | Functional Immunology
The overarching goal of the Laboratory for Functional Immunology is to improve our understanding of cellular and molecular mechanisms underlying the regulation of germinal centre responses in vaccination, infection, and cancer, to dissect mechanistic targets that could be used to improve vaccines and therapeutic strategies.
Pinto-Fernández Group | Translational Ubiquitomics - Cancer Immunology
Our laboratory studies how cellular ubiquitination and ISGylation regulate innate immune signalling, cancer immune evasion, and immune resilience. We aim to understand how cancer cells fine-tune interferon responses to alter antigen presentation, immune recognition, and therapy sensitivity, with the long-term goal of translating these mechanisms into therapeutic targets. To address these questions, we combine state-of-the-art mass spectrometry-based omics approaches, including proteomics and lipidomics, with functional genomics, cellular biology, and immunology assays.
Dong Group | T cell responses against Viruses & Cancer
Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.
Bottomley Group | Organismal and Local Factors Driving Effective Peripheral Immunity
Exploring the impact of systemic and tissue-specific factors in determining immune response against viral infection and malignancy