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One of the major breakthroughs of cancer immunotherapy has come from blocking immune checkpoint molecules on tumor-reactive T cells. Now, two studies examine targeting of a novel immune checkpoint, NKG2A, that can be expressed on both NK cells and on CD8+ T cells, either combined with a tumor-targeting antibody or with a tumor-specific vaccine.

Original publication

DOI

10.1016/j.cell.2018.11.048

Type

Journal article

Journal

Cell

Publication Date

13/12/2018

Volume

175

Pages

1720 - 1722