Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

ABSTRACTCytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38+HLA-DR+) and apoptosis-vulnerable (CD95+Bcl-2−) CD4+and CD8+T cells increased substantially during acute CMV infection. The frequency of activated CD4+T cells was strongly associated with both concurrent CMV coinfection (P= 0.001) and HIV-1 viral load (P= 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P= 0.02) and CD8 (P< 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants.

Original publication

DOI

10.1128/jvi.00790-12

Type

Journal article

Journal

Journal of Virology

Publisher

American Society for Microbiology

Publication Date

15/10/2012

Volume

86

Pages

11373 - 11379