Beginnings: The molecular pathology of hemoglobin

Higgs D., Badat M.

The study of hemoglobin and its disorders (hemoglobinopathies) is inextricably linked to the development of molecular medicine in general. This chapter considers the structure, synthesis, and genetic control of the human globin genes and describes the molecular pathology of the thalassemias. Through this many of the basic principles of gene transcription and translation are elucidated. Current standard of care and future curative strategies are discussed, including gene therapy and editing.

DOI

10.1002/9781394180486.ch1

Type

Chapter

Book title

Molecular Hematology

Publication Date

08/03/2024

Pages

1 - 16

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