Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

In mammals, most new mutations occur in males. But a study of the evolution of a human X to Y chromosomal translocation has revealed a sex bias much lower than previous estimates. Patterns of substitution suggest that differential methylation between male and female germ lines is a key determinant of the mutation rate.

Type

Journal article

Journal

Curr Biol

Publication Date

16/11/2000

Volume

10

Pages

R834 - R835

Keywords

Animals, CpG Islands, DNA Methylation, Evolution, Molecular, Female, Humans, Male, Sexual Maturation, Translocation, Genetic, X Chromosome, Y Chromosome