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'Popeye, the Sailor' cartoons taught children that eating spinach boosts strength and helps defend against bullies. Lötscher and colleagues report that dietary deficiency of magnesium ions (Mg2+), against which eating spinach is an excellent antidote, impairs the activity of a key adhesion molecule, LFA-1, and hinders the ability of CD8+ T cells to grapple with assorted bullies, such as tumors and bacteria.

Original publication

DOI

10.1016/j.it.2022.02.004

Type

Journal article

Journal

Trends in immunology

Publication Date

04/2022

Volume

43

Pages

277 - 279

Addresses

Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: vardhans@mskcc.org.

Keywords

CD8-Positive T-Lymphocytes, Humans, Magnesium, Cell Adhesion Molecules, Lymphocyte Function-Associated Antigen-1, Child