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With continuous T cell receptor (TCR) signaling, T cells can attenuate subsequent antigen responses through adaptive tolerance, thus averting autoimmunity, but potentially also providing refuge to developing cancers. Elliot and coworkers add to our understanding of adaptation via immune checkpoints by exploiting accelerated in vivo adaptive tolerance in the face of strong TCR signaling.

Original publication

DOI

10.1016/j.it.2021.10.014

Type

Journal article

Journal

Trends in immunology

Publication Date

12/2021

Volume

42

Pages

1066 - 1068

Addresses

Kennedy Institute of Rheumatology, Nuffield Department of Rheumatology, Orthopedics, and Musculoskeletal Sciences, The University of Oxford, Oxford OX3 7FY, UK.

Keywords

T-Lymphocytes, Humans, Receptors, Antigen, T-Cell, Signal Transduction, Autoimmunity, Immune Tolerance