Innate Lymphocyte Mechanisms in Skin Diseases.

Chen Y-L., Hardman CS., Yadava K., Ogg G.

Innate lymphocyte populations are emerging as key effectors in tissue homeostasis, microbial defense, and inflammatory skin disease. The cells are evolutionarily ancient and carry conserved principles of function, which can be achieved through shared or unique specific mechanisms. Recent technological and treatment advances have provided insight into heterogeneity within and between individuals and species. Similar pathways can extend through to adaptive lymphocytes, which softens the margins with innate lymphocyte populations and allows investigation of nonredundant pathways of immunity and inflammation that might be amenable to therapeutic intervention. Here, we review advances in understanding of innate lymphocyte biology with a focus on skin disease and the roles of commensal and pathogen responses and tissue homeostasis.

DOI

10.1146/annurev-immunol-082919-093554

Type

Book

Publication Date

04/2020

Volume

38

Pages

171 - 202

Addresses

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Headington, Oxford, OX3 9DS, United Kingdom.

Keywords

Lymphocyte Subsets, Animals, Humans, Skin Diseases, Signal Transduction, Homeostasis, Host-Pathogen Interactions, Immunity, Innate, Microbiota, Biomarkers

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