Yang Liu

Yang Liu is a member of Prof. Xuetao Cao’s team and a principal investigator at Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences. She obtained an M.D. in immunology from Peking Union Medical College & Tsinghua University under the supervision of Prof. Xuetao Cao in 2019. She was invited to attend the 68^th Lindau Nobel Laureate Meeting in Physiology or Medicine held in Germany (2018) and selected as a member of the MIT Technology Review Innovators Under 35 Asia Pacific (2022).

Yang is interested in the epigenetic and metabolic regulation of host-pathogen interaction. Her findings add new mechanistic insight into the host defense against invading pathogens through epigenetic and metabolic regulation of innate immunity and inflammation, and provide new potential targets for the intervention and treatment of infectious diseases.

N⁶-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication.

Yang Liu, Yuling You, Zhike Lu, Jiang Yang, Panpan Li, Lun Liu, Henan Xu, Yamei Niu, Xuetao Cao*. Science. 2019; 365 (6458):1171-1176.

m⁶A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration.

Yang Liu*, Renjie Song, Lu Zhao, Zhike Lu, Yini Li, Xinyi Zhan, Fengjiao Lu, Jiang Yang, Yamei Niu, Xuetao Cao*. Signal Transduction and Targeted Therapy. 2022; 7 (1):194.

The RNA m⁶A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression.

Yang Liu*, Renjie Song, Zhike Lu, Lu Zhao, Xinyi Zhan, Yini Li, Xuetao Cao. Cellular & Molecular Immunology. 2024; 21(1):6-18.

Characteristics and significance of the pre-metastatic niche.

Yang Liu, Xuetao Cao*. Cancer Cell. 2016; 30 (5):668-681.

Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression.

Lu Zhao, Renjie Song, Yang Liu*. European Journal of Immunology. 2023; 53(12): e2350536.