Eltrombopag: a powerful chelator of cellular or extracellular iron(III) alone or combined with a second chelator
Vlachodimitropoulou E., Chen Y-L., Garbowski M., Koonyosying P., Psaila B., Sola-Visner M., Cooper N., Hider R., Porter J.
Key PointsELT is a powerful iron chelator, mobilizing iron and ferritin, reducing ROS, and restoring insulin production at clinically achievable levels. ELT enhances cellular iron chelation when combined with clinically available iron chelators through the shuttling of iron(III).