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Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.

Original publication

DOI

10.1016/j.hoc.2021.01.002

Type

Journal article

Journal

Hematology/oncology clinics of North America

Publication Date

04/2021

Volume

35

Pages

279 - 293

Addresses

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine and NIHR Biomedical Research Centre, University of Oxford, Headley Way, Oxford OX39DS, UK.

Keywords

Humans, Neoplasms, Myeloproliferative Disorders, Fibrosis, Gene Expression Profiling, Genomics, Neoplastic Stem Cells, Single-Cell Analysis